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Spatial distribution of resting-state BOLD regional homogeneity as a predictor of brain glucose uptake: A study in healthy aging.
Bernier, Michaël; Croteau, Etienne; Castellano, Christian-Alexandre; Cunnane, Stephen C; Whittingstall, Kevin.
Afiliação
  • Bernier M; Departments of Nuclear Medicine and Radiobiology, Université de Sherbrooke, Canada. Electronic address: michael.bernier@usherbrooke.ca.
  • Croteau E; Departments of Pharmacology and Physiology, Université de Sherbrooke, Canada; Research Center on Aging, CIUSSS de l'Estrie - CHUS, Sherbrooke, Canada.
  • Castellano CA; Research Center on Aging, CIUSSS de l'Estrie - CHUS, Sherbrooke, Canada.
  • Cunnane SC; Departments of Medecine, Université de Sherbrooke, Canada; Departments of Pharmacology and Physiology, Université de Sherbrooke, Canada; Research Center on Aging, CIUSSS de l'Estrie - CHUS, Sherbrooke, Canada.
  • Whittingstall K; Departments of Radiology, Université de Sherbrooke, Canada; CR-CHUS, Sherbrooke, Canada.
Neuroimage ; 150: 14-22, 2017 04 15.
Article em En | MEDLINE | ID: mdl-28130193
Positron emission tomography using [18F]-fluorodeoxyglucose (PET-FDG) is the primary imaging modality used to measure glucose metabolism in the brain (CMRGlu). CMRGlu has been used as a biomarker of brain aging and neurodegenerative diseases, but the complexity and invasive nature of PET often limits its use in research. There is therefore great interest in developing non-invasive metrics for estimating brain CMRGlu. We therefore investigated resting state fMRI metrics such as regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF) and regional global connectivity (Closeness) with multiple analytical approaches to determine their relationship to CMRGlu. We investigated this relation in two distinct cognitively healthy populations separated by age (27 young adults and 35 older adults). Overall, we found that both regionally and across participants, ReHo strongly correlated with CMRGlu in healthy young and older adults. Moreover, ReHo demonstrated the same age-related differences as CMRGlu throughout all cortical regions, particularly in the default network and frontal areas.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Mapeamento Encefálico / Interpretação de Imagem Assistida por Computador / Glucose Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Mapeamento Encefálico / Interpretação de Imagem Assistida por Computador / Glucose Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article