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Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress.
Ramot, Assaf; Jiang, Zhiying; Tian, Jin-Bin; Nahum, Tali; Kuperman, Yael; Justice, Nicholas; Chen, Alon.
Afiliação
  • Ramot A; Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
  • Jiang Z; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
  • Tian JB; Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, Texas, USA.
  • Nahum T; Department of Integrative Biology and Pharmacology, University of Texas Health Sciences Center, Houston, Texas, USA.
  • Kuperman Y; Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
  • Justice N; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
  • Chen A; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel.
Nat Neurosci ; 20(3): 385-388, 2017 Mar.
Article em En | MEDLINE | ID: mdl-28135239
ABSTRACT
The hypothalamic-pituitary-adrenal axis is a pivotal component of an organism's response to stressful challenges, and dysfunction of this neuroendocrine axis is associated with a variety of physiological and psychological pathologies. We found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic-pituitary-adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Núcleo Hipotalâmico Paraventricular / Sistema Hipófise-Suprarrenal / Estresse Fisiológico / Estresse Psicológico / Receptores de Hormônio Liberador da Corticotropina / Sistema Hipotálamo-Hipofisário Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Núcleo Hipotalâmico Paraventricular / Sistema Hipófise-Suprarrenal / Estresse Fisiológico / Estresse Psicológico / Receptores de Hormônio Liberador da Corticotropina / Sistema Hipotálamo-Hipofisário Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article