Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress.
Nat Neurosci
; 20(3): 385-388, 2017 Mar.
Article
em En
| MEDLINE
| ID: mdl-28135239
ABSTRACT
The hypothalamic-pituitary-adrenal axis is a pivotal component of an organism's response to stressful challenges, and dysfunction of this neuroendocrine axis is associated with a variety of physiological and psychological pathologies. We found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic-pituitary-adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Núcleo Hipotalâmico Paraventricular
/
Sistema Hipófise-Suprarrenal
/
Estresse Fisiológico
/
Estresse Psicológico
/
Receptores de Hormônio Liberador da Corticotropina
/
Sistema Hipotálamo-Hipofisário
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article