Massively multiplex single-cell Hi-C.
Nat Methods
; 14(3): 263-266, 2017 03.
Article
em En
| MEDLINE
| ID: mdl-28135255
ABSTRACT
We present single-cell combinatorial indexed Hi-C (sciHi-C), a method that applies combinatorial cellular indexing to chromosome conformation capture. In this proof of concept, we generate and sequence six sciHi-C libraries comprising a total of 10,696 single cells. We use sciHi-C data to separate cells by karyotypic and cell-cycle state differences and identify cell-to-cell heterogeneity in mammalian chromosomal conformation. Our results demonstrate that combinatorial indexing is a generalizable strategy for single-cell genomics.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Genoma Humano
/
Cromossomos
/
Genômica
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Análise de Célula Única
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Conformação Molecular
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article