Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells.

Hale, Malika; Mesojednik, Taylor; Romano Ibarra, Guillermo S; Sahni, Jaya; Bernard, Alison; Sommer, Karen; Scharenberg, Andrew M; Rawlings, David J; Wagner, Thor A

Hale, Malika; Mesojednik, Taylor; Romano Ibarra, Guillermo S; Sahni, Jaya; Bernard, Alison; Sommer, Karen; Scharenberg, Andrew M; Rawlings, David J; Wagner, Thor A.

Afiliação

Hale M; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Mesojednik T; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Romano Ibarra GS; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Sahni J; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Bernard A; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Sommer K; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Scharenberg AM; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington, Seattle, WA 98101, USA; Department of Immunology, University of Washington, Seattle, WA 98101, USA.
Rawlings DJ; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington, Seattle, WA 98101, USA; Department of Immunology, University of Washington, Seattle, WA 98101, USA. Electr
Wagner TA; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington, Seattle, WA 98101, USA. Electronic address: thor.wagner@seattlechildrens.org.

Mol Ther ; 25(3): 570-579, 2017 03 01.

Article em En | MEDLINE | ID: mdl-28143740

Assuntos

Anticorpos Anti-HIV/imunologia; Infecções por HIV/imunologia; Infecções por HIV/terapia; HIV-1/imunologia; Subpopulações de Linfócitos/imunologia; Subpopulações de Linfócitos/metabolismo; Receptores de Antígenos de Linfócitos T/metabolismo; Proteínas Recombinantes de Fusão; Anticorpos Neutralizantes/genética; Anticorpos Neutralizantes/imunologia; Anticorpos Neutralizantes/metabolismo; Citotoxicidade Imunológica; Epitopos/imunologia; Ordem dos Genes; Engenharia Genética; Vetores Genéticos/genética; Anticorpos Anti-HIV/genética; Anticorpos Anti-HIV/metabolismo; Proteína gp120 do Envelope de HIV/imunologia; Infecções por HIV/genética; Humanos; Imunoterapia; Ativação Linfocitária/imunologia; Receptores de Antígenos de Linfócitos T/genética; Receptores CCR5/genética; Receptores CCR5/metabolismo; Anticorpos de Cadeia Única; Replicação Viral

Palavras-chave

CAR T cell; HIV; cell therapy; chimeric antigen receptor; gene editing

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Receptores de Antígenos de Linfócitos T / Anticorpos Anti-HIV / Infecções por HIV / Subpopulações de Linfócitos / HIV-1 Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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