Safety, efficacy and pharmacokinetics of rVIII-SingleChain in children with severe hemophilia A: results of a multicenter clinical trial.

Stasyshyn, O; Djambas Khayat, C; Iosava, G; Ong, J; Abdul Karim, F; Fischer, K; Veldman, A; Blackman, N; St Ledger, K; Pabinger, I

Stasyshyn, O; Djambas Khayat, C; Iosava, G; Ong, J; Abdul Karim, F; Fischer, K; Veldman, A; Blackman, N; St Ledger, K; Pabinger, I.

Afiliação

Stasyshyn O; Institute of Blood Pathology and Transfusion Medicine, National Academy of Medical Sciences of Ukraine, Lviv, Ukraine.
Djambas Khayat C; Lebanon Department of Pediatrics, Hotel Dieu de France Hospital, Beirut, Lebanon.
Iosava G; JSC Scientific-Research Institute of Hematology and Transfusiology, Tbilisi, Georgia.
Ong J; Brokenshire Integrated Health Ministries, Inc., Davao, Philippines.
Abdul Karim F; Hemophilia Clinic, National Blood Centre, Kuala Lumpur, Malaysia.
Fischer K; Van Creveldkliniek, University Medical Center Utrecht, Utrecht, the Netherlands.
Veldman A; Clinical R&D, CSL Behring, Marburg, Germany.
Blackman N; Clinical R&D, CSL Behring, King of Prussia, PA, USA.
St Ledger K; Clinical R&D, CSL Behring, King of Prussia, PA, USA.
Pabinger I; Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University Vienna, Vienna, Austria.

J Thromb Haemost ; 15(4): 636-644, 2017 04.

Article em En | MEDLINE | ID: mdl-28166608

Assuntos

Fator VIII/uso terapêutico; Hemofilia A/tratamento farmacológico; Criança; Pré-Escolar; Esquema de Medicação; Fator VIII/farmacocinética; Hemorragia; Hemostasia/efeitos dos fármacos; Hemostáticos/uso terapêutico; Humanos; Lactente; Recém-Nascido; Segurança do Paciente; Pediatria; Fenótipo; Ligação Proteica; Índice de Gravidade de Doença; Resultado do Tratamento; Fator de von Willebrand/química

Palavras-chave

clinical trial; factor VIII; hemophilia A; pediatric; pharmacokinetics; safety

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator VIII / Hemofilia A Tipo de estudo: Clinical_trials / Guideline Limite: Child / Child, preschool / Humans / Infant / Newborn Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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