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Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10.
Halstrom, Samuel; Thomson, Rachel; Goullee, Hayley; Baltic, Svetlana; Allcock, Richard; Temple, Suzanna E L; Price, Patricia.
Afiliação
  • Halstrom S; School of Medicine, University of Queensland, Brisbane, QLD, Australia; School of Biomedical Science, Curtin University, Perth, W.A., Australia; Gallipoli Medical Research Foundation, Greenslopes Private Hospital, Brisbane, QLD, Australia.
  • Thomson R; School of Medicine, University of Queensland, Brisbane, QLD, Australia; Gallipoli Medical Research Foundation, Greenslopes Private Hospital, Brisbane, QLD, Australia.
  • Goullee H; Harry Perkins Institute of Medical Research, Perth, W.A., Australia.
  • Baltic S; Institute for Respiratory Health, University of Western Australia, Perth, W.A., Australia.
  • Allcock R; School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, W.A., Australia.
  • Temple SE; Harry Perkins Institute of Medical Research, Perth, W.A., Australia.
  • Price P; School of Biomedical Science, Curtin University, Perth, W.A., Australia; School of Physiology, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: patricia.price@curtin.edu.au.
Hum Immunol ; 78(4): 391-393, 2017 Apr.
Article em En | MEDLINE | ID: mdl-28174026
Although exposure to potentially pathogenic nontuberculous mycobacteria (NTM) via soil and domestic water supplies is common, pulmonary infection and disease are confined to a small proportion of older individuals. Previously, alleles of a polymorphism in IL10 (rs1800896) were associated with NTM disease and we demonstrated elevated production of IL-10 by blood leukocytes from patients with pulmonary NTM. Here seven additional polymorphisms in IL10 were investigated in a larger cohort of Caucasian controls and patients with pulmonary NTM disease. This demonstrated a significant association between pulmonary NTM disease and one polymorphism (rs1518111) in strong linkage disequilibrium with rs1800896.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia / Interleucina-10 / População Branca / Micobactérias não Tuberculosas / Infecções por Mycobacterium não Tuberculosas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia / Interleucina-10 / População Branca / Micobactérias não Tuberculosas / Infecções por Mycobacterium não Tuberculosas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article