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Clinical utility of spot urine protein-to-creatinine ratio modified by estimated daily creatinine excretion in children.
Yang, Eun Mi; Yoon, Bo Ae; Kim, Soo Wan; Kim, Chan Jong.
Afiliação
  • Yang EM; Department of Pediatrics, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju, 61469, Republic of Korea.
  • Yoon BA; Department of Pediatrics, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju, 61469, Republic of Korea.
  • Kim SW; Department of Internal Medicine, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju, 61469, Republic of Korea.
  • Kim CJ; Department of Pediatrics, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju, 61469, Republic of Korea. cjkim@jnu.ac.kr.
Pediatr Nephrol ; 32(6): 1045-1051, 2017 06.
Article em En | MEDLINE | ID: mdl-28188437
ABSTRACT

BACKGROUND:

The spot urine protein-to-creatinine ratio (UPCR) is widely used to predict 24-h urine protein (24-h UP) excretion. In patients with low daily urine creatinine excretion (UCr), however, the UPCR may overestimate 24-h UP. The aim of this study was to predict 24-h UP using UPCR adjusted by estimated 24-h UCr in children.

METHODS:

This study included 442 children whose 24-h UP and spot UPCR were measured concomitantly. Estimated 24-h UCr was calculated using three previously existing equations. We estimated the 24-h UP excretion from UPCR by multiplying the estimated UCr. The results were compared with the measured 24-h UP.

RESULTS:

There was a strong correlation between UPCR and 24-h UP (r = 0.801, P < 0.001), and the correlation improved after multiplying the UPCR by the measured UCr (r = 0.847, P < 0.001). Using the estimated UCr rather than the measured UCr, there was high accuracy and strong correlation between the estimated UPCR weighted by the Cockcroft-Gault equation and 24-h UP. Improvement was also observed in the subgroup (proteinuria vs. non-proteinuria) analysis, particularly in the proteinuria group.

CONCLUSIONS:

The spot UPCR multiplied by the estimated UCr improved the accuracy of prediction of the 24-h UP in children.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteinúria / Creatinina / Testes de Função Renal Tipo de estudo: Observational_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteinúria / Creatinina / Testes de Função Renal Tipo de estudo: Observational_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article