Direct arterial injection of hyperpolarized <sup>13</sup> C-labeled substrates into rat tumors for rapid MR detection of metabolism with minimal substrate dilution.

Reynolds, Steven; Metcalf, Stephen; Cochrane, Edward J; Collins, Rebecca C; Jones, Simon; Paley, Martyn N J; Tozer, Gillian M

Direct arterial injection of hyperpolarized ¹³ C-labeled substrates into rat tumors for rapid MR detection of metabolism with minimal substrate dilution.

Reynolds, Steven; Metcalf, Stephen; Cochrane, Edward J; Collins, Rebecca C; Jones, Simon; Paley, Martyn N J; Tozer, Gillian M.

Afiliação

Reynolds S; Academic Unit of Radiology, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.
Metcalf S; Tumour Microcirculation Group, Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom.
Cochrane EJ; Department of Chemistry, Dainton Building, University of Sheffield, Brook Hill, Sheffield, United Kingdom.
Collins RC; Department of Chemistry, Dainton Building, University of Sheffield, Brook Hill, Sheffield, United Kingdom.
Jones S; Department of Chemistry, Dainton Building, University of Sheffield, Brook Hill, Sheffield, United Kingdom.
Paley MNJ; Academic Unit of Radiology, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.
Tozer GM; Tumour Microcirculation Group, Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom.

Magn Reson Med ; 78(6): 2116-2126, 2017 Dec.

Article em En | MEDLINE | ID: mdl-28191664

Assuntos

Isótopos de Carbono/química; Espectroscopia de Ressonância Magnética; Neoplasias/diagnóstico por imagem; Animais; Artérias/diagnóstico por imagem; Sistemas de Liberação de Medicamentos; Artérias Epigástricas/diagnóstico por imagem; Feminino; Veia Femoral/diagnóstico por imagem; Gadolínio/química; Masculino; Metástase Neoplásica; Neoplasias/metabolismo; Imagem Óptica; Perfusão; Fosforilação; Ácido Pirúvico/química; Ratos; Espectrofotometria; Estilbenos/química

Palavras-chave

13C-glucose; 13C-pyruvate; P22 tumor; combretastatin; hyperpolarization; intra-arterial

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Isótopos de Carbono / Espectroscopia de Ressonância Magnética / Neoplasias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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