Multiple-scale neuroendocrine signals connect brain and pituitary hormone rhythms.
Proc Natl Acad Sci U S A
; 114(9): 2379-2382, 2017 02 28.
Article
em En
| MEDLINE
| ID: mdl-28193889
ABSTRACT
Small assemblies of hypothalamic "parvocellular" neurons release their neuroendocrine signals at the median eminence (ME) to control long-lasting pituitary hormone rhythms essential for homeostasis. How such rapid hypothalamic neurotransmission leads to slowly evolving hormonal signals remains unknown. Here, we show that the temporal organization of dopamine (DA) release events in freely behaving animals relies on a set of characteristic features that are adapted to the dynamic dopaminergic control of pituitary prolactin secretion, a key reproductive hormone. First, locally generated DA release signals are organized over more than four orders of magnitude (0.001 Hz-10 Hz). Second, these DA events are finely tuned within and between frequency domains as building blocks that recur over days to weeks. Third, an integration time window is detected across the ME and consists of high-frequency DA discharges that are coordinated within the minutes range. Thus, a hierarchical combination of time-scaled neuroendocrine signals displays local-global integration to connect brain-pituitary rhythms and pace hormone secretion.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Hipófise-Suprarrenal
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Hipófise
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Prolactina
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Ritmo Ultradiano
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Hipotálamo
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Eminência Mediana
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article