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Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling.
Kedzierski, Lukasz; Tate, Michelle D; Hsu, Alan C; Kolesnik, Tatiana B; Linossi, Edmond M; Dagley, Laura; Dong, Zhaoguang; Freeman, Sarah; Infusini, Giuseppe; Starkey, Malcolm R; Bird, Nicola L; Chatfield, Simon M; Babon, Jeffrey J; Huntington, Nicholas; Belz, Gabrielle; Webb, Andrew; Wark, Peter Ab; Nicola, Nicos A; Xu, Jianqing; Kedzierska, Katherine; Hansbro, Philip M; Nicholson, Sandra E.
Afiliação
  • Kedzierski L; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Tate MD; Department of Medical Biology, University of Melbourne, Parkville, Australia.
  • Hsu AC; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Australia.
  • Kolesnik TB; Monash University, Clayton, Australia.
  • Linossi EM; Priority Research Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute and The University of Newcastle, Newcastle, Australia.
  • Dagley L; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Dong Z; Department of Medical Biology, University of Melbourne, Parkville, Australia.
  • Freeman S; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Infusini G; Department of Medical Biology, University of Melbourne, Parkville, Australia.
  • Starkey MR; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Bird NL; Department of Medical Biology, University of Melbourne, Parkville, Australia.
  • Chatfield SM; Shanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
  • Babon JJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Huntington N; Department of Medical Biology, University of Melbourne, Parkville, Australia.
  • Belz G; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Webb A; Department of Medical Biology, University of Melbourne, Parkville, Australia.
  • Wark PA; Priority Research Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute and The University of Newcastle, Newcastle, Australia.
  • Nicola NA; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Australia.
  • Xu J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Kedzierska K; Department of Medical Biology, University of Melbourne, Parkville, Australia.
  • Hansbro PM; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Nicholson SE; Department of Medical Biology, University of Melbourne, Parkville, Australia.
Elife ; 62017 02 14.
Article em En | MEDLINE | ID: mdl-28195529
ABSTRACT
Influenza virus infections have a significant impact on global human health. Individuals with suppressed immunity, or suffering from chronic inflammatory conditions such as COPD, are particularly susceptible to influenza. Here we show that suppressor of cytokine signaling (SOCS) five has a pivotal role in restricting influenza A virus in the airway epithelium, through the regulation of epidermal growth factor receptor (EGFR). Socs5-deficient mice exhibit heightened disease severity, with increased viral titres and weight loss. Socs5 levels were differentially regulated in response to distinct influenza viruses (H1N1, H3N2, H5N1 and H11N9) and were reduced in primary epithelial cells from COPD patients, again correlating with increased susceptibility to influenza. Importantly, restoration of SOCS5 levels restricted influenza virus infection, suggesting that manipulating SOCS5 expression and/or SOCS5 targets might be a novel therapeutic approach to influenza.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Transdução de Sinais / Citocinas / Proteínas Supressoras da Sinalização de Citocina / Receptores ErbB Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Transdução de Sinais / Citocinas / Proteínas Supressoras da Sinalização de Citocina / Receptores ErbB Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article