Elevated basal antibody-dependent cell-mediated cytotoxicity (ADCC) and high epidermal growth factor receptor (EGFR) expression predict favourable outcome in patients with locally advanced head and neck cancer treated with cetuximab and radiotherapy.

Lattanzio, Laura; Denaro, Nerina; Vivenza, Daniela; Varamo, Chiara; Strola, Giuliana; Fortunato, Mirella; Chamorey, Emmanuel; Comino, Alberto; Monteverde, Martino; Lo Nigro, Cristiana; Milano, Gerard; Merlano, Marco

Lattanzio, Laura; Denaro, Nerina; Vivenza, Daniela; Varamo, Chiara; Strola, Giuliana; Fortunato, Mirella; Chamorey, Emmanuel; Comino, Alberto; Monteverde, Martino; Lo Nigro, Cristiana; Milano, Gerard; Merlano, Marco.

Afiliação

Lattanzio L; Laboratory of Cancer Genetics and Translational Oncology, Oncology Department, S. Croce & Carle Teaching Hospital, via Carle 25, 12100, Cuneo, Italy. lauretta.lattanzio@gmail.com.
Denaro N; Medical Oncology, Oncology Department, S. Croce & Carle Teaching Hospital, Cuneo, Italy.
Vivenza D; Laboratory of Cancer Genetics and Translational Oncology, Oncology Department, S. Croce & Carle Teaching Hospital, via Carle 25, 12100, Cuneo, Italy.
Varamo C; Laboratory of Cancer Genetics and Translational Oncology, Oncology Department, S. Croce & Carle Teaching Hospital, via Carle 25, 12100, Cuneo, Italy.
Strola G; Pathology Department, S. Croce & Carle Teaching Hospital, Cuneo, Italy.
Fortunato M; Pathology Department, S. Croce & Carle Teaching Hospital, Cuneo, Italy.
Chamorey E; Oncopharmacology Unit, Centre A. Lacassagne, Nice, France.
Comino A; Pathology Department, S. Croce & Carle Teaching Hospital, Cuneo, Italy.
Monteverde M; Laboratory of Cancer Genetics and Translational Oncology, Oncology Department, S. Croce & Carle Teaching Hospital, via Carle 25, 12100, Cuneo, Italy.
Lo Nigro C; Laboratory of Cancer Genetics and Translational Oncology, Oncology Department, S. Croce & Carle Teaching Hospital, via Carle 25, 12100, Cuneo, Italy.
Milano G; Oncopharmacology Unit, Centre A. Lacassagne, Nice, France.
Merlano M; Laboratory of Cancer Genetics and Translational Oncology, Oncology Department, S. Croce & Carle Teaching Hospital, via Carle 25, 12100, Cuneo, Italy.

Cancer Immunol Immunother ; 66(5): 573-579, 2017 May.

Article em En | MEDLINE | ID: mdl-28197666

Assuntos

Antineoplásicos/uso terapêutico; Carcinoma de Células Escamosas/tratamento farmacológico; Carcinoma de Células Escamosas/radioterapia; Cetuximab/uso terapêutico; Receptores ErbB/metabolismo; Neoplasias de Cabeça e Pescoço/tratamento farmacológico; Neoplasias de Cabeça e Pescoço/radioterapia; Adulto; Idoso; Idoso de 80 Anos ou mais; Citotoxicidade Celular Dependente de Anticorpos; Carcinoma de Células Escamosas/enzimologia; Carcinoma de Células Escamosas/imunologia; Linhagem Celular Tumoral; Quimiorradioterapia; Feminino; Neoplasias de Cabeça e Pescoço/enzimologia; Neoplasias de Cabeça e Pescoço/imunologia; Humanos; Masculino; Pessoa de Meia-Idade; Carcinoma de Células Escamosas de Cabeça e Pescoço; Resultado do Tratamento

Palavras-chave

ADCC; Cetuximab; EGFR; Head and neck cancer; Outcome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Escamosas / Receptores ErbB / Cetuximab / Neoplasias de Cabeça e Pescoço / Antineoplásicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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