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LASER server: ancestry tracing with genotypes or sequence reads.
Taliun, Daniel; Chothani, Sonia P; Schönherr, Sebastian; Forer, Lukas; Boehnke, Michael; Abecasis, Gonçalo R; Wang, Chaolong.
Afiliação
  • Taliun D; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.
  • Chothani SP; Computational and Systems Biology, Genome Institute of Singapore, Singapore 138672, Singapore.
  • Schönherr S; Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck 6020, Austria.
  • Forer L; Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck 6020, Austria.
  • Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.
  • Abecasis GR; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.
  • Wang C; Computational and Systems Biology, Genome Institute of Singapore, Singapore 138672, Singapore.
Bioinformatics ; 33(13): 2056-2058, 2017 Jul 01.
Article em En | MEDLINE | ID: mdl-28200055
ABSTRACT

SUMMARY:

To enable direct comparison of ancestry background in different studies, we developed LASER to estimate individual ancestry by placing either sezquenced or genotyped samples in a common ancestry space, regardless of the sequencing strategy or genotyping array used to characterize each sample. Here we describe the LASER server to facilitate application of the method to a wide range of genetic studies. The server provides genetic ancestry estimation for different geographic regions and user-friendly interactive visualization of the results. AVAILABILITY AND IMPLEMENTATION The LASER server is freely accessible at http//laser.sph.umich.edu/. CONTACT dtaliun@umich.edu or wangcl@gis.a-star.edu.sg. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Software / Análise de Sequência de DNA / Grupos Populacionais / Filogeografia Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Software / Análise de Sequência de DNA / Grupos Populacionais / Filogeografia Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article