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Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis.
Morel, Jerome; Hargreaves, Iain; Brealey, David; Neergheen, Viruna; Backman, Janne T; Lindig, Sandro; Bläss, Marcus; Bauer, Michael; McAuley, Daniel F; Singer, Mervyn.
Afiliação
  • Morel J; Departement d'anesthesie et reanimation, CHU Saint Etienne, Saint Etienne, France.
  • Hargreaves I; Bloomsbury Institute of Intensive Care Medicine, University College London, London WC1E 6BT, U.K.
  • Brealey D; Neurometabolic Unit, National Hospital, Queen Square, London, WC1N 3BG, U.K.
  • Neergheen V; Bloomsbury Institute of Intensive Care Medicine, University College London, London WC1E 6BT, U.K.
  • Backman JT; Neurometabolic Unit, National Hospital, Queen Square, London, WC1N 3BG, U.K.
  • Lindig S; Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Bläss M; Department of Anaesthesiology and Intensive Care Therapy and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.
  • Bauer M; Department of Anaesthesiology and Intensive Care Therapy and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.
  • McAuley DF; Department of Anaesthesiology and Intensive Care Therapy and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.
  • Singer M; Centre for Infection and Immunity, Queen's University of Belfast and Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, U.K.
Clin Sci (Lond) ; 131(8): 747-758, 2017 Apr 25.
Article em En | MEDLINE | ID: mdl-28202686
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sepse / Inibidores de Hidroximetilglutaril-CoA Redutases / Sinvastatina / Hidratação Tipo de estudo: Clinical_trials Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sepse / Inibidores de Hidroximetilglutaril-CoA Redutases / Sinvastatina / Hidratação Tipo de estudo: Clinical_trials Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article