Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice.
Science
; 355(6326): 756-760, 2017 02 17.
Article
em En
| MEDLINE
| ID: mdl-28209901
ABSTRACT
Glaucomas are neurodegenerative diseases that cause vision loss, especially in the elderly. The mechanisms initiating glaucoma and driving neuronal vulnerability during normal aging are unknown. Studying glaucoma-prone mice, we show that mitochondrial abnormalities are an early driver of neuronal dysfunction, occurring before detectable degeneration. Retinal levels of nicotinamide adenine dinucleotide (NAD+, a key molecule in energy and redox metabolism) decrease with age and render aging neurons vulnerable to disease-related insults. Oral administration of the NAD+ precursor nicotinamide (vitamin B3), and/or gene therapy (driving expression of Nmnat1, a key NAD+-producing enzyme), was protective both prophylactically and as an intervention. At the highest dose tested, 93% of eyes did not develop glaucoma. This supports therapeutic use of vitamin B3 in glaucoma and potentially other age-related neurodegenerations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
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Glaucoma
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Niacinamida
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Doenças Neurodegenerativas
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Mitocôndrias
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NAD
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article