Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes.

Willcox, Abby; Richardson, Sarah J; Walker, Lucy S K; Kent, Sally C; Morgan, Noel G; Gillespie, Kathleen M

Willcox, Abby; Richardson, Sarah J; Walker, Lucy S K; Kent, Sally C; Morgan, Noel G; Gillespie, Kathleen M.

Afiliação

Willcox A; Diabetes and Metabolism, Level 2 Learning and Research, University of Bristol, Southmead Hospital, Bristol, BS10 5NB, UK.
Richardson SJ; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
Walker LSK; Institute of Immunity and Transplantation, UCL Division of Infection and Immunity, Royal Free Campus, London, UK.
Kent SC; Division of Diabetes, Department of Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA.
Morgan NG; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
Gillespie KM; Diabetes and Metabolism, Level 2 Learning and Research, University of Bristol, Southmead Hospital, Bristol, BS10 5NB, UK. K.M.Gillespie@bristol.ac.uk.

Diabetologia ; 60(7): 1294-1303, 2017 07.

Article em En | MEDLINE | ID: mdl-28213757

Assuntos

Linfócitos B/citologia; Diabetes Mellitus Tipo 1/imunologia; Centro Germinativo/imunologia; Linfonodos/imunologia; Linfonodos/patologia; Pâncreas/patologia; Adolescente; Adulto; Idoso; Animais; Autoanticorpos/imunologia; Autoantígenos/imunologia; Criança; Pré-Escolar; Estudos de Coortes; Células Dendríticas/metabolismo; Diabetes Mellitus Tipo 1/metabolismo; Feminino; Cabras; Humanos; Processamento de Imagem Assistida por Computador; Insulina/metabolismo; Células Secretoras de Insulina/metabolismo; Ilhotas Pancreáticas/metabolismo; Antígeno Ki-67/metabolismo; Masculino; Camundongos; Microscopia de Fluorescência; Fenótipo; Coelhos; Adulto Jovem

Palavras-chave

Histology; Islet autoimmunity; Pancreatic lymph nodes; Type 1 diabetes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pâncreas / Linfócitos B / Centro Germinativo / Diabetes Mellitus Tipo 1 / Linfonodos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Animals / Child / Child, preschool / Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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