An endoplasmic reticulum-engineered yeast platform for overproduction of triterpenoids.

Arendt, Philipp; Miettinen, Karel; Pollier, Jacob; De Rycke, Riet; Callewaert, Nico; Goossens, Alain

Arendt, Philipp; Miettinen, Karel; Pollier, Jacob; De Rycke, Riet; Callewaert, Nico; Goossens, Alain.

Afiliação

Arendt P; Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium; Center for Plant Systems Biology, VIB, 9052 Ghent, Belgium; Laboratory for Protein Biochemistry and Biomolecular Engineering, Department of Biochemistry and Microbiology, Ghent University, B-9000 Ghent, Belg
Miettinen K; Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium; Center for Plant Systems Biology, VIB, 9052 Ghent, Belgium.
Pollier J; Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium; Center for Plant Systems Biology, VIB, 9052 Ghent, Belgium.
De Rycke R; Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium; Center for Plant Systems Biology, VIB, 9052 Ghent, Belgium.
Callewaert N; Laboratory for Protein Biochemistry and Biomolecular Engineering, Department of Biochemistry and Microbiology, Ghent University, B-9000 Ghent, Belgium; VIB Medical Biotechnology Center, B-9000 Ghent, Belgium.
Goossens A; Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium; Center for Plant Systems Biology, VIB, 9052 Ghent, Belgium. Electronic address: alain.goossens@ugent.vib.be.

Metab Eng ; 40: 165-175, 2017 03.

Article em En | MEDLINE | ID: mdl-28216107

Assuntos

Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas/genética; Retículo Endoplasmático/fisiologia; Engenharia Metabólica/métodos; Fosfatidato Fosfatase/genética; Saccharomyces cerevisiae/fisiologia; Saponinas/biossíntese; Vias Biossintéticas/genética; Edição de Genes/métodos; Melhoramento Genético/métodos; Redes e Vias Metabólicas/genética; Proteínas de Saccharomyces cerevisiae; Saponinas/isolamento & purificação; Triterpenos/isolamento & purificação; Triterpenos/metabolismo; Regulação para Cima/fisiologia

Palavras-chave

Combinatorial biosynthesis; Cytochrome P450; Metabolic engineering; Saponins; Terpenoids

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Saponinas / Fosfatidato Fosfatase / Retículo Endoplasmático / Engenharia Metabólica / Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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