Cryo-EM structure of the replisome reveals multiple interactions coordinating DNA synthesis.

Kulczyk, Arkadiusz W; Moeller, Arne; Meyer, Peter; Sliz, Piotr; Richardson, Charles C

Kulczyk, Arkadiusz W; Moeller, Arne; Meyer, Peter; Sliz, Piotr; Richardson, Charles C.

Afiliação

Kulczyk AW; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115; arek@hms.harvard.edu ccr@hms.harvard.edu.
Moeller A; Department of Molecular Biology and Genetics, The Danish Research Institute of Translational Neuroscience, Aarhus University, 8000 Aarhus, Denmark.
Meyer P; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
Sliz P; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
Richardson CC; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115; arek@hms.harvard.edu ccr@hms.harvard.edu.

Proc Natl Acad Sci U S A ; 114(10): E1848-E1856, 2017 03 07.

Article em En | MEDLINE | ID: mdl-28223502

Assuntos

Replicação do DNA/genética; DNA/química; Complexos Multienzimáticos/química; Tiorredoxinas/química; Bacteriófago T7/química; Bacteriófago T7/genética; Bacteriófago T7/ultraestrutura; Microscopia Crioeletrônica; DNA/biossíntese; DNA/genética; DNA/ultraestrutura; Complexos Multienzimáticos/genética; Complexos Multienzimáticos/ultraestrutura; Domínios Proteicos; Tiorredoxinas/genética; Tiorredoxinas/ultraestrutura

Palavras-chave

DNA polymerase; DNA replication; coordination of leading- and lagging-strands synthesis; cryo-EM structure; replisome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiorredoxinas / DNA / Replicação do DNA / Complexos Multienzimáticos Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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