Ethyl Pyruvate Attenuates Early Brain Injury Following Subarachnoid Hemorrhage in the Endovascular Perforation Rabbit Model Possibly Via Anti-inflammation and Inhibition of JNK Signaling Pathway.

Lv, Tao; Miao, Yi-Feng; Jin, Yi-Chao; Yang, Shao-Feng; Wu, Hui; Dai, Jiong; Zhang, Xiao-Hua

Lv, Tao; Miao, Yi-Feng; Jin, Yi-Chao; Yang, Shao-Feng; Wu, Hui; Dai, Jiong; Zhang, Xiao-Hua.

Afiliação

Lv T; Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Road, Shanghai, 200127, China.
Miao YF; Department of Neurosurgery, Ren Ji Hospital South Campus, School of Medicine, Shanghai Jiao Tong University, No. 2000 Jiangyue Road, Shanghai, 201112, China.
Jin YC; Department of Neurosurgery, Ren Ji Hospital South Campus, School of Medicine, Shanghai Jiao Tong University, No. 2000 Jiangyue Road, Shanghai, 201112, China.
Yang SF; Department of Neurosurgery, Ren Ji Hospital South Campus, School of Medicine, Shanghai Jiao Tong University, No. 2000 Jiangyue Road, Shanghai, 201112, China.
Wu H; Department of Neurosurgery, Ren Ji Hospital South Campus, School of Medicine, Shanghai Jiao Tong University, No. 2000 Jiangyue Road, Shanghai, 201112, China.
Dai J; Department of Neurosurgery, Ren Ji Hospital South Campus, School of Medicine, Shanghai Jiao Tong University, No. 2000 Jiangyue Road, Shanghai, 201112, China. daijiong@126.com.
Zhang XH; Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Road, Shanghai, 200127, China. zxh196909@163.com.

Neurochem Res ; 42(4): 1044-1056, 2017 Apr.

Article em En | MEDLINE | ID: mdl-28236213

Assuntos

Anti-Inflamatórios/uso terapêutico; Lesões Encefálicas/prevenção & controle; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Piruvatos/uso terapêutico; Hemorragia Subaracnóidea/tratamento farmacológico; Animais; Anti-Inflamatórios/farmacologia; Lesões Encefálicas/diagnóstico por imagem; Lesões Encefálicas/metabolismo; Procedimentos Endovasculares/efeitos adversos; Sistema de Sinalização das MAP Quinases/fisiologia; Imageamento por Ressonância Magnética/métodos; Masculino; Piruvatos/farmacologia; Coelhos; Distribuição Aleatória; Hemorragia Subaracnóidea/diagnóstico por imagem; Hemorragia Subaracnóidea/metabolismo

Palavras-chave

Early brain injury (EBI); Ethyl pyruvate (EP); Jun N-terminal kinase (JNK); Subarachnoid hemorrhage (SAH); Tumor necrosis factor-α (TNF-α)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piruvatos / Hemorragia Subaracnóidea / Lesões Encefálicas / Sistema de Sinalização das MAP Quinases / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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