Molecular Factors Governing the Liquid and Glassy States Recrystallization of Celecoxib in Binary Mixtures with Excipients of Different Molecular Weights.

Grzybowska, K; Chmiel, K; Knapik-Kowalczuk, J; Grzybowski, A; Jurkiewicz, K; Paluch, M

Grzybowska, K; Chmiel, K; Knapik-Kowalczuk, J; Grzybowski, A; Jurkiewicz, K; Paluch, M.

Afiliação

Grzybowska K; Institute of Physics, University of Silesia in Katowice , ul. Uniwersytecka 4, 40-007 Katowice, Poland.
Chmiel K; Silesian Center for Education and Interdisciplinary Research , ul. 75 Pulku Piechoty 1a, 41-500 Chorzów, Poland.
Knapik-Kowalczuk J; Institute of Physics, University of Silesia in Katowice , ul. Uniwersytecka 4, 40-007 Katowice, Poland.
Grzybowski A; Silesian Center for Education and Interdisciplinary Research , ul. 75 Pulku Piechoty 1a, 41-500 Chorzów, Poland.
Jurkiewicz K; Institute of Physics, University of Silesia in Katowice , ul. Uniwersytecka 4, 40-007 Katowice, Poland.
Paluch M; Silesian Center for Education and Interdisciplinary Research , ul. 75 Pulku Piechoty 1a, 41-500 Chorzów, Poland.

Mol Pharm ; 14(4): 1154-1168, 2017 04 03.

Article em En | MEDLINE | ID: mdl-28241116

Assuntos

Celecoxib/química; Excipientes/química; Varredura Diferencial de Calorimetria/métodos; Cristalização/métodos; Estabilidade de Medicamentos; Simulação de Dinâmica Molecular; Peso Molecular; Polímeros/química; Povidona/química; Termodinâmica; Difração de Raios X/métodos

Palavras-chave

amorphous drug; celecoxib; crystallization; devitrification; glass transition; molecular dynamics; physical stability; solid dispersion

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Excipientes / Celecoxib Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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