[Influence of n-hexane on vascular endothelial active substances in brain tissue in mice].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
; 35(1): 49-50, 2017 Jan 20.
Article
em Zh
| MEDLINE
| ID: mdl-28241704
ABSTRACT
Objective:
To investigate the influence of n-hexane on vascular endothelial active substances in brain tissue in mice and its significance.Methods:
A total of 48 healthy Kunming mice were randomly divided into high-dose exposure group, middle-dose exposure group, low-dose exposure group, and control group, with 12 mice in each group. All groups except the control group were exposed to n-hexane via static inhalation (0.035 g/L, 0.018 g/L, and 0.009 g/L for the high-, middle-, and low-dose exposure groups, respectively) 4 hours a day for 21 days. the mice in the control groups were not exposed to n-hexane. After the exposure, the lev-els of endothelin-1 (ET-1) , nitric oxide (NO) , and angiotensin II (Ang II) in brain tissue were measured in all groups.Results:
There were significant differences in the levels of ET-1, NO, and Ang II between the three ex-posure groups and the control group (P<0.05). Compared with the control group, the high-and middle-dose expo-sure group had significant increases in the levels of ET-1 and Ang II and the high-dose exposure group had a sig-nificant reduction in the level of NO (P<0.05 or P<0.01).Conclusion:
n-Hexane can affect the vascular endothe-lial active substances in brain tissue in mice, and the changes and imbalance in vascular endothelial active sub-stances may be one of the reasons for central nervous system impairment caused by n-hexane.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Endotélio Vascular
/
Hexanos
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2017
Tipo de documento:
Article