Inhibition of LTB4 binding to human neutrophils by nordihydroguaiaretic acid.
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; 21(3-4): 358-60, 1987 Aug.
Article
em En
| MEDLINE
| ID: mdl-2825484
ABSTRACT
Nordihydroguaiaretic acid (NDGA) was investigated for its ability to interact with leukotriene B4 receptors on human polymorphonuclear leukocytes (hPMNs). 3H-LTB4 binding to specific receptors was reduced in a dose-dependent manner with maximal reduction at 100 microM NDGA and an IC50 of about 50 microM. Binding of another inflammatory stimulus. N-formyl-norleucyl-leucyl-phenylalanine (FNLP) was not affected by similar treatment. Chemotaxis and enzyme release stimulated by LTB4 and oligopeptide were inhibited by NDGA. In addition, LTB4-triggered inflammation in vivo in mice was inhibited by systemic administration of NDGA. These data suggest that LTB4 receptor antagonism may contribute to inhibition of inflammation by NDGA.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Masoprocol
/
Catecóis
/
Leucotrieno B4
/
Neutrófilos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article