Markers of nucleic acids and proteins oxidation among office workers exposed to air pollutants including (nano)TiO2 particles.
Neuro Endocrinol Lett
; 37(Suppl1): 13-16, 2016 Dec 18.
Article
em En
| MEDLINE
| ID: mdl-28263525
ABSTRACT
OBJECTIVES:
Experimental studies using nanoscale TiO2 have documented lung injury, inflammation, oxidative stress, and genotoxicity. Human health data are extremely scarce.METHODS:
In exhaled breath condensate (EBC) and urine of 22 office employees occupationally exposed to TiO2 during their visit in the production workshops for average 14±9 min/day a panel of biomarkers of nucleic acids and proteins oxidation was studied, specifically 8-hydroxy-2-deoxyguanosine (8-OHdG), 8-hydroxyguanosine (8-OHG), 5-hydroxymethyl uracil (5-OHMeU), o-tyrosine (o-Tyr), 3-chlorotyrosine (3-ClTyr), and 3-nitrotyrosine (3-NOTyr). Examination was performed also in 14 comparable controls.RESULTS:
The median respirable TiO2 mass concentration in the workshops was 0.40 mg/m3, median number concentration was 2.32×104 particles/cm3 with 80% of the particles being <100 nm in diameter. All 6 markers of oxidation were elevated in EBC in factory office employees relative to controls (p<0.01). Significant association was found between their job in TiO2 production plant and 5 markers of oxidation (except 3-NOTyr) in the EBC in multivariate analysis. No elevation of markers was detected in the urine.CONCLUSION:
This pilot study suggests that even short nanoTiO2 exposure may lead to pulmonary oxidative stress; however this effect may be short-term and reversible. The clinical significance of these findings is unclear and more studies are needed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Titânio
/
Exposição Ocupacional
/
Estresse Oxidativo
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Poluentes Atmosféricos
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Nanopartículas Metálicas
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Doenças Profissionais
Limite:
Adult
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article