Prophylaxis with Isavuconazole or Posaconazole Protects Immunosuppressed Mice from Pulmonary Mucormycosis.
Antimicrob Agents Chemother
; 61(5)2017 05.
Article
em En
| MEDLINE
| ID: mdl-28264840
ABSTRACT
We assessed prophylactic or continuous therapy of isavuconazole, posaconazole, or voriconazole in treating pulmonary murine mucormycosis. In the prophylaxis studies, only isavuconazole treatment resulted in significantly improved survival and lowered tissue fungal burden of immunosuppressed mice infected with Rhizopus delemar. In the continuous treatment studies, isavuconazole and posaconazole, but not voriconazole, equally prolonged survival time and lowered tissue fungal burden compared to placebo-treated mice. These results support the use of isavuconazole and posaconazole in prophylaxis treatment.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Triazóis
/
Voriconazol
/
Pneumopatias Fúngicas
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Mucormicose
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Antifúngicos
/
Nitrilas
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article