Your browser doesn't support javascript.
loading
Prophylaxis with Isavuconazole or Posaconazole Protects Immunosuppressed Mice from Pulmonary Mucormycosis.
Gebremariam, Teclegiorgis; Alkhazraji, Sondus; Baldin, Clara; Kovanda, Laura; Wiederhold, Nathan P; Ibrahim, Ashraf S.
Afiliação
  • Gebremariam T; Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA.
  • Alkhazraji S; Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA.
  • Baldin C; Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA.
  • Kovanda L; Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA.
  • Wiederhold NP; University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
  • Ibrahim AS; Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA ibrahim@labiomed.org.
Antimicrob Agents Chemother ; 61(5)2017 05.
Article em En | MEDLINE | ID: mdl-28264840
ABSTRACT
We assessed prophylactic or continuous therapy of isavuconazole, posaconazole, or voriconazole in treating pulmonary murine mucormycosis. In the prophylaxis studies, only isavuconazole treatment resulted in significantly improved survival and lowered tissue fungal burden of immunosuppressed mice infected with Rhizopus delemar. In the continuous treatment studies, isavuconazole and posaconazole, but not voriconazole, equally prolonged survival time and lowered tissue fungal burden compared to placebo-treated mice. These results support the use of isavuconazole and posaconazole in prophylaxis treatment.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Triazóis / Voriconazol / Pneumopatias Fúngicas / Mucormicose / Antifúngicos / Nitrilas Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Triazóis / Voriconazol / Pneumopatias Fúngicas / Mucormicose / Antifúngicos / Nitrilas Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article