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Spirooxindole synthesis via palladium-catalyzed dearomative reductive-Heck reaction.
Liu, Ren-Rong; Xu, Yang; Liang, Ren-Xiao; Xiang, Bin; Xie, Hu-Jun; Gao, Jian-Rong; Jia, Yi-Xia.
Afiliação
  • Liu RR; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China. yxjia@zjut.edu.cn.
  • Xu Y; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China. yxjia@zjut.edu.cn.
  • Liang RX; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China. yxjia@zjut.edu.cn.
  • Xiang B; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China. yxjia@zjut.edu.cn.
  • Xie HJ; Department of Applied Chemistry, Zhejiang Gongshang University, Hangzhou 310035, China.
  • Gao JR; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China. yxjia@zjut.edu.cn.
  • Jia YX; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China. yxjia@zjut.edu.cn.
Org Biomol Chem ; 15(13): 2711-2715, 2017 Mar 28.
Article em En | MEDLINE | ID: mdl-28267180
ABSTRACT
Palladium-catalyzed intramolecular dearomative reductive-Heck reaction of C2-substituted indoles is developed, which provides access to structurally diverse 3,2'-spiropyrrolidine oxindoles. By changing the hydride source to AcONa base, direct C3-arylation products [2,3-b]quinolinones are achieved in good yields. The reaction of C2-substituted benzofuran is also realized, delivering the desired spiro-product.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article