Convergent synthesis of a deuterium-labeled serine dipeptide lipid for analysis of biological samples.
J Labelled Comp Radiopharm
; 60(6): 274-285, 2017 05 30.
Article
em En
| MEDLINE
| ID: mdl-28271544
Bacterial serine dipeptide lipids are known to promote inflammatory processes and are detected in human tissues associated with periodontal disease or atherosclerosis. Accurate quantification of bacterial serine lipid, specifically lipid 654 [((S)-15-methyl-3-((13-methyltetradecanoyl)oxy)hexadecanoyl)glycyl-l-serine, (3S)-l-serine] isolated from Porphyromonas gingivalis, in biological samples requires the preparation of a stable isotope internal standard for sample supplementation and subsequent mass spectrometric analysis. This report describes the convergent synthesis of a deuterium-substituted serine dipeptide lipid, which is an isotopically labeled homologue that represents a dominant form of serine dipeptide lipid recovered in bacteria.
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Coleções:
01-internacional
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MEDLINE
Assunto principal:
Serina
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Fatores de Virulência
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Deutério
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Dipeptídeos
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Metabolismo dos Lipídeos
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Lipopeptídeos
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Lipídeos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article