Your browser doesn't support javascript.
loading
The role of checkpoint inhibitors immunotherapy in advanced non-small cell lung cancer in the elderly.
Sgambato, Assunta; Casaluce, Francesca; Gridelli, Cesare.
Afiliação
  • Sgambato A; a Division of Medical Oncology , 'S. G. Moscati' Hospital , Avellino , Italy.
  • Casaluce F; a Division of Medical Oncology , 'S. G. Moscati' Hospital , Avellino , Italy.
  • Gridelli C; a Division of Medical Oncology , 'S. G. Moscati' Hospital , Avellino , Italy.
Expert Opin Biol Ther ; 17(5): 565-571, 2017 05.
Article em En | MEDLINE | ID: mdl-28276698
INTRODUCTION: Immune checkpoint inhibition is a novel treatment modality that has brought a new hope to patients with advanced NSCLC. Several molecules targeting cytotoxic T-lymphocyte antigen 4 (CTLA4) or programmed cell death 1 receptor/programmed death ligand-1 (PD1/PD-L1) pathways are under evaluation in NSCLC and three of them are currently approved: nivolumab and atezolizumab for advanced NSCLC after prior chemotherapy and pembrolizumab for advanced NSCLC expressing PD-L1 ≥ 1% after at least one prior chemotherapy regimen and > 50% as a first-line response. Areas covered: To date, the efficacy and toxicity of immune checkpoint inhibitors in the elderly is unclear because available studies involved mainly a low number of elderly patients. In this paper, the authors discuss the frailty of the elderly patient and the challenges of choosing the best therapeutic strategy, focusing on the role of immune checkpoint inhibitors. Expert opinion: There are several outstanding goals that need to be met for the proper and safe use of immunotherapeutic drugs. In terms of the elderly, it is true that age-tailored clinical trials are needed to confirm the real impact of immunotherapy and harmonize the standard of care in this specific demographic.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Genes cdc / Imunoterapia / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies Limite: Aged / Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Genes cdc / Imunoterapia / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies Limite: Aged / Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article