5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain.
Somatosens Mot Res
; 34(2): 72-79, 2017 06.
Article
em En
| MEDLINE
| ID: mdl-28276837
ABSTRACT
Epigenetic mechanisms are increasingly implicated in chronic pain pathology. In this study, we demonstrate that the novel epigenetic mark 5-hydroxymethylcytosine (5hmC) is present in dorsal root ganglia (DRG) neurons and glia, and its levels increase following nerve injury. Furthermore, we show that the 5hmC-generating Ten-eleven translocation 1-3 (TET1-3) proteins are expressed in a cell-type specific manner in the DRG, with Tet3 displaying differential upregulation after injury, suggesting a potential role in neuropathic pain.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Proto-Oncogênicas
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5-Metilcitosina
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Epigênese Genética
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Proteínas de Ligação a DNA
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Gânglios Espinais
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Neuralgia
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article