A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy.

Araínga, Mariluz; Edagwa, Benson; Mosley, R Lee; Poluektova, Larisa Y; Gorantla, Santhi; Gendelman, Howard E

Araínga, Mariluz; Edagwa, Benson; Mosley, R Lee; Poluektova, Larisa Y; Gorantla, Santhi; Gendelman, Howard E.

Afiliação

Araínga M; Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198-5880, USA.
Edagwa B; Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198-5880, USA.
Mosley RL; Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198-5880, USA.
Poluektova LY; Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198-5880, USA.
Gorantla S; Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198-5880, USA.
Gendelman HE; Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198-5880, USA. hegendel@unmc.edu.

Retrovirology ; 14(1): 17, 2017 03 09.

Article em En | MEDLINE | ID: mdl-28279181

Assuntos

Antirretrovirais/administração & dosagem; Infecções por HIV/tratamento farmacológico; Infecções por HIV/virologia; HIV-1/crescimento & desenvolvimento; Macrófagos/virologia; Animais; DNA Viral/análise; DNA Viral/genética; Reservatórios de Doenças; HIV-1/fisiologia; Humanos; Camundongos SCID; Plasma/virologia; Reação em Cadeia da Polimerase; Provírus/genética; RNA Viral/análise; Resultado do Tratamento; Carga Viral; Latência Viral

Palavras-chave

Antiretroviral therapy; HIV-1; Humanized mice; Monocytemacrophage; T effector cells; Viral reservoirs

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV-1 / Antirretrovirais / Macrófagos Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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