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T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.
Hui, Enfu; Cheung, Jeanne; Zhu, Jing; Su, Xiaolei; Taylor, Marcus J; Wallweber, Heidi A; Sasmal, Dibyendu K; Huang, Jun; Kim, Jeong M; Mellman, Ira; Vale, Ronald D.
Afiliação
  • Hui E; Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA.
  • Cheung J; Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA.
  • Zhu J; Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA.
  • Su X; Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA.
  • Taylor MJ; Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA.
  • Wallweber HA; Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA.
  • Sasmal DK; Institute for Molecular Engineering, University of Chicago, IL 60637, USA.
  • Huang J; Institute for Molecular Engineering, University of Chicago, IL 60637, USA.
  • Kim JM; Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA.
  • Mellman I; Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA. mellman.ira@gene.com ron.vale@ucsf.edu.
  • Vale RD; Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA. mellman.ira@gene.com ron.vale@ucsf.edu.
Science ; 355(6332): 1428-1433, 2017 03 31.
Article em En | MEDLINE | ID: mdl-28280247
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Antígenos CD28 / Antígeno B7-H1 / Receptor de Morte Celular Programada 1 / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Antígenos CD28 / Antígeno B7-H1 / Receptor de Morte Celular Programada 1 / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article