Attenuated in vitro effects of IFN-&#945;, IL-2 and IL-12 on functional and receptor characteristics of peripheral blood lymphocytes in metastatic melanoma patients.

Mirjacic Martinovic, Katarina M; Vuletic, Ana M; Lj Babovic, Nada; Dzodic, Radan R; Konjevic, Gordana M; Jurisic, Vladimir B

Attenuated in vitro effects of IFN-α, IL-2 and IL-12 on functional and receptor characteristics of peripheral blood lymphocytes in metastatic melanoma patients.

Mirjacic Martinovic, Katarina M; Vuletic, Ana M; Lj Babovic, Nada; Dzodic, Radan R; Konjevic, Gordana M; Jurisic, Vladimir B.

Afiliação

Mirjacic Martinovic KM; Department of Experimental Oncology, Institute of Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia.
Vuletic AM; Department of Experimental Oncology, Institute of Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia.
Lj Babovic N; Department of Medical Oncology, Institute of Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia.
Dzodic RR; Surgical Oncology Clinic, Institute of Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia; School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Beograd, Serbia.
Konjevic GM; Department of Experimental Oncology, Institute of Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia; School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Beograd, Serbia.
Jurisic VB; Faculty of Medical Sciences, University of Kragujevac, P. Box 124, 34000 Kragujevac, Serbia. Electronic address: vdvd@lycos.com.

Cytokine ; 96: 30-40, 2017 08.

Article em En | MEDLINE | ID: mdl-28282548

Assuntos

Interferon-alfa/farmacologia; Interleucina-12/farmacologia; Interleucina-2/farmacologia; Leucócitos Mononucleares/efeitos dos fármacos; Melanoma/sangue; Adulto; Idoso; Testes Imunológicos de Citotoxicidade; Feminino; Humanos; Imunomodulação; Interleucina-18/farmacologia; Ativação Linfocitária; Masculino; Pessoa de Meia-Idade; Subfamília K de Receptores Semelhantes a Lectina de Células NK; Metástase Neoplásica; Perforina/genética; Perforina/metabolismo; Fator de Transcrição STAT1/genética; Fator de Transcrição STAT5/genética; Transdução de Sinais/efeitos dos fármacos; Linfócitos T Reguladores/efeitos dos fármacos

Palavras-chave

Cytotoxicity; IFN-α/IL-2/IL-12/IL-18; Lymphocytes; Metastatic melanoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucócitos Mononucleares / Interleucina-2 / Interferon-alfa / Interleucina-12 / Melanoma Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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