Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins.

Tripathi, Arati; Mandon, Elisabet C; Gilmore, Reid; Rapoport, Tom A

Tripathi, Arati; Mandon, Elisabet C; Gilmore, Reid; Rapoport, Tom A.

Afiliação

Tripathi A; From the Howard Hughes Medical Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and arati_tripathi@hms.harvard.edu.
Mandon EC; the Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605.
Gilmore R; the Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605.
Rapoport TA; From the Howard Hughes Medical Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and tom_rapoport@hms.harvard.edu.

J Biol Chem ; 292(19): 8007-8018, 2017 05 12.

Article em En | MEDLINE | ID: mdl-28286332

Assuntos

Ascomicetos/metabolismo; Proteínas Fúngicas/metabolismo; Proteínas de Choque Térmico HSP70/metabolismo; Saccharomyces cerevisiae/metabolismo; Adenosina Trifosfatases/metabolismo; Cristalografia por Raios X; Citosol/metabolismo; Mutação; Peptídeos/química; Ligação Proteica; Domínios Proteicos; Processamento de Proteína Pós-Traducional; Transporte Proteico; Ribossomos/metabolismo; Proteínas de Saccharomyces cerevisiae/metabolismo

Palavras-chave

70 kilodalton heat shock protein (Hsp70); Sec71; Sec72; Ssa1; Ssb1; TPR; endoplasmic reticulum (ER); protein structure; protein translocation; structure-function

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ascomicetos / Saccharomyces cerevisiae / Proteínas Fúngicas / Proteínas de Choque Térmico HSP70 Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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