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[Galectin-3 in Patients With Paroxysmal and Persistent Atrial Fibrillation and Metabolic Syndrome].
A, V A; Zaslavskaya, E L; Soboleva, A V; Baranova, E I; Listopad, O V; Nifontov, S E; Nrady, A O; Shlyakhto, E V.
Afiliação
  • A VA; Pavlov First Saint-Petersburg State Medical University, Russian.
  • Zaslavskaya EL; Federal Almazov North-West Medical Research Centere, Saint-Petersburg, Russian.
  • Soboleva AV; Pavlov First Saint-Petersburg State Medical University, Russian.
  • Baranova EI; Federal Almazov North-West Medical Research Centere, Saint-Petersburg, Russian.
  • Listopad OV; Pavlov First Saint-Petersburg State Medical University, Russian.
  • Nifontov SE; Federal Almazov North-West Medical Research Centere, Saint-Petersburg, Russian.
  • Nrady AO; Pavlov First Saint-Petersburg State Medical University, Russian.
  • Shlyakhto EV; Federal Almazov North-West Medical Research Centere, Saint-Petersburg, Russian.
Kardiologiia ; 56(6): 41-45, 2016 06.
Article em Ru | MEDLINE | ID: mdl-28290846
OBJECTIVE: To evaluate serum galectin 3 and to determine the potential clinical value of this parameter in patients with atrial fibrillation - AF (paroxysmal and persistent) and metabolic syndrome (MS). DESIGN AND METHODS: We examined 100 patients with MS (50 with paroxysmal or persistent AF and 50 without arrhythmia) and 50 healthy persons. Serum galectin 3 measured by ELISA method, ECHO cardiography was performed to all examined persons. RESULTS: Galectin 3 in patients with MS and AF was higher, than in patients with MS without arrhythmia and much more higher than galectin 3 in healthy persons 0,72 (0,44;1,36), 0,44 (0,42;1,22) and 0,32 (0,28;0,42) ng/ml (<0,01). In patients with persistent AF levels of galectin 3 is higher than in patients with paroxysmal AF. Positive correlation between the levels of galectin 3 and duration arrhythmia was revealed (r=0,301; p<0,01). Higher level of galectin 3 was revealed in patients with frequent paroxysms of AF and ineffective antiarrhythmic therapy. CONCLUSION: Marker of myocardial fibrosis serum galectin 3 in patients with atrial fibrillation and metabolic syndrome is higher than in patients with the metabolic syndrome, without this arrhythmia and higher than in healthy controls. In patients with persistent AF level of galectin 3 was higher than in patients with paroxysmal AF.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrilação Atrial / Síndrome Metabólica / Galectina 3 Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: Ru Ano de publicação: 2016 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrilação Atrial / Síndrome Metabólica / Galectina 3 Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: Ru Ano de publicação: 2016 Tipo de documento: Article