Nanoskin® Subcutaneous Implant in Guinea Pigs.
Ophthalmic Plast Reconstr Surg
; 34(2): 136-139, 2018.
Article
em En
| MEDLINE
| ID: mdl-28296654
ABSTRACT
PURPOSE:
To evaluate the suitability of Nanoskin, a biomaterial derived from bacterial cellulose, as an alternate material for repairing the posterior lamellae of the eyelids.METHODS:
Forty guinea pigs received a fragment of Nanoskin subcutaneously in the dorsal region. The animals received Nanoskin (group 1) or Nanoskin coated with a gelatin layer (group 2). The animals were observed daily for over 7, 30, 90, or 180 days with the subcutaneous implants in place. The animals were euthanized at a designated time and the Nanoskin was removed for histologic, morphometric, and transmission electron microscopy evaluation.RESULTS:
The results were similar for both groups. The subcutaneously implanted Nanoskin resulted in good tissue integration, induced mild inflammation, and was surrounded by a delicate pseudocapsule.CONCLUSION:
The good tissue integration of Nanoskin in study indicates that it may be a potential material for application as a substitute of posterior eyelid lamellar tissue. Further clinical studies are required to confirm the preliminary outcomes of this experimental study.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Próteses e Implantes
/
Materiais Biocompatíveis
/
Celulose
/
Nanoestruturas
/
Pálpebras
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article