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T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP.
Perruzza, Lisa; Gargari, Giorgio; Proietti, Michele; Fosso, Bruno; D'Erchia, Anna Maria; Faliti, Caterina Elisa; Rezzonico-Jost, Tanja; Scribano, Daniela; Mauri, Laura; Colombo, Diego; Pellegrini, Giovanni; Moregola, Annalisa; Mooser, Catherine; Pesole, Graziano; Nicoletti, Mauro; Norata, Giuseppe Danilo; Geuking, Markus B; McCoy, Kathy D; Guglielmetti, Simone; Grassi, Fabio.
Afiliação
  • Perruzza L; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland; Graduate School for Cellular and Biomedical Sciences, University of Bern, 3001 Bern 9, Switzerland.
  • Gargari G; Department of Food, Environmental, and Nutritional Sciences (DeFENS), Università degli Studi di Milano, 20133 Milan, Italy.
  • Proietti M; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.
  • Fosso B; Institute of Biomembranes and Bioenergetics, National Research Council, 70126 Bari, Italy.
  • D'Erchia AM; Institute of Biomembranes and Bioenergetics, National Research Council, 70126 Bari, Italy; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70126 Bari, Italy.
  • Faliti CE; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland; Graduate School for Cellular and Biomedical Sciences, University of Bern, 3001 Bern 9, Switzerland.
  • Rezzonico-Jost T; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.
  • Scribano D; Department of Medical and Oral Sciences and Biotechnologies, University "Gabriele D'Annunzio", 66100 Chieti, Italy; Departement of Public Health and Infectious Diseases, University "La Sapienza" of Rome, 00185 Rome, Italy.
  • Mauri L; Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano, 20129 Milan, Italy.
  • Colombo D; Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano, 20129 Milan, Italy.
  • Pellegrini G; Laboratory for Animal Model Pathology, Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
  • Moregola A; Department of Pharmacological and Biomolecular Sciences (DiSFeB), Università degli Studi di Milano, 20133 Milan, Italy.
  • Mooser C; Maurice Müller Laboratories, Universitätsklinik für Viszerale Chirurgie und Medizin (UVCM), University of Bern, 3010 Bern, Switzerland.
  • Pesole G; Institute of Biomembranes and Bioenergetics, National Research Council, 70126 Bari, Italy; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70126 Bari, Italy.
  • Nicoletti M; Department of Medical and Oral Sciences and Biotechnologies, University "Gabriele D'Annunzio", 66100 Chieti, Italy.
  • Norata GD; Department of Pharmacological and Biomolecular Sciences (DiSFeB), Università degli Studi di Milano, 20133 Milan, Italy; School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6845, Australia.
  • Geuking MB; Maurice Müller Laboratories, Universitätsklinik für Viszerale Chirurgie und Medizin (UVCM), University of Bern, 3010 Bern, Switzerland; Department of Microbiology, Immunology and Infectious Diseases and Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, Univer
  • McCoy KD; Maurice Müller Laboratories, Universitätsklinik für Viszerale Chirurgie und Medizin (UVCM), University of Bern, 3010 Bern, Switzerland; Department of Physiology and Pharmacology and Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calg
  • Guglielmetti S; Department of Food, Environmental, and Nutritional Sciences (DeFENS), Università degli Studi di Milano, 20133 Milan, Italy.
  • Grassi F; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland; Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano, 20129 Milan, Italy; Istituto Nazionale Genetica Molecolare "Romeo ed Enrica Invernizzi
Cell Rep ; 18(11): 2566-2575, 2017 03 14.
Article em En | MEDLINE | ID: mdl-28297661
ABSTRACT
The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer's patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity is important for generating a diverse bacterial community in the gut and that sensing of microbiota-derived extracellular ATP via P2X7 promotes the generation of a proficient gut ecosystem for metabolic homeostasis. The results of this study indicate that Tfh cells play a role in host-microbiota mutualism beyond protecting the intestinal mucosa by induction of affinity-matured IgA and suggest that extracellular ATP constitutes an inter-kingdom signaling molecule important for selecting a beneficial microbial community for the host via P2X7-mediated regulation of B cell help.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trifosfato de Adenosina / Linfócitos T Auxiliares-Indutores / Espaço Extracelular / Microbioma Gastrointestinal / Homeostase Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trifosfato de Adenosina / Linfócitos T Auxiliares-Indutores / Espaço Extracelular / Microbioma Gastrointestinal / Homeostase Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article