Sleep Deprivation Induced Plasma Amyloid-ß Transport Disturbance in Healthy Young Adults.
J Alzheimers Dis
; 57(3): 899-906, 2017.
Article
em En
| MEDLINE
| ID: mdl-28304302
ABSTRACT
BACKGROUND:
Sleep is an important physiological process and beneficial in the removal of brain metabolites and functional recovery. Prior studies have shown that sleep disorders are significant risk factors for Alzheimer's disease (AD).OBJECTIVE:
The present study was designed to characterize the effect of short-term total sleep deprivation (TSD) on plasma amyloid-ß (Aß) concentrations.METHODS:
A clinical trial was conducted between March 1, 2016, and April 1, 2016. Twenty volunteers (age 27.3±3.4 years) with normal cognitive function and sleeping habits were recruited from the local population. Participants underwent 24âh of TSD. Periprocedural blood samples were collected to compare the changes of plasma Aß42, Aß40, low-density lipoprotein receptor-related protein (sLRP-1), soluble receptors for advanced glycation end products (sRAGE), and serum superoxide dismutase (SOD) and malonaldehyde (MDA).RESULTS:
TSD increased morning plasma Aß40 levels by 32.6% (pâ<â0.001) and decreased the Aß42/Aß40 ratio by 19.3% (pâ<â0.001). A positive relationship was found between TSD duration and plasma Aß40 level (râ=â0.51, pâ<â0.001) and Aß40/Aß42 ratio (râ=â0.25, pâ=â0.003). Plasma concentrations of sLRP1 (pâ=â0.018) and sRAGE (pâ=â0.001) decreased significantly after TSD. Aß40 and Aß42 plasma concentrations correlated with plasma levels of sLRP1 and sRAGE. Serum SOD decreased after TSD (pâ=â0.005), whereas serum MDA was increased (pâ=â0.001).CONCLUSION:
Sleep deprivation can lead to an elevation of plasma Aß40 and decrease of the Aß42/Aß40 ratio. The underlying mechanisms may be related to increased oxidative stress and impaired peripheral Aß clearance as pathomechanisms of AD.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Privação do Sono
/
Peptídeos beta-Amiloides
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article