The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.

Rudenko, Iakov N; Kaganovich, Alice; Langston, Rebekah G; Beilina, Aleksandra; Ndukwe, Kelechi; Kumaran, Ravindran; Dillman, Allissa A; Chia, Ruth; Cookson, Mark R

Rudenko, Iakov N; Kaganovich, Alice; Langston, Rebekah G; Beilina, Aleksandra; Ndukwe, Kelechi; Kumaran, Ravindran; Dillman, Allissa A; Chia, Ruth; Cookson, Mark R.

Afiliação

Rudenko IN; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A. cookson@mail.nih.gov iakov.rudenko@stonybrookmedicine.edu.
Kaganovich A; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A.
Langston RG; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A.
Beilina A; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A.
Ndukwe K; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A.
Kumaran R; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A.
Dillman AA; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A.
Chia R; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A.
Cookson MR; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A. cookson@mail.nih.gov iakov.rudenko@stonybrookmedicine.edu.

Biochem J ; 474(9): 1547-1558, 2017 04 24.

Article em En | MEDLINE | ID: mdl-28320779

Assuntos

Predisposição Genética para Doença; Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina/genética; Mutação; Doença de Parkinson/genética; Ubiquitina-Proteína Ligases/metabolismo; Técnicas de Silenciamento de Genes; Células HEK293; Humanos; Complexo de Endopeptidases do Proteassoma/metabolismo; Proteólise; Fatores de Risco; Ubiquitina-Proteína Ligases/genética

Palavras-chave

CHIP; G-proteins; Parkinson's disease; proteasome; protein stability

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Predisposição Genética para Doença / Ubiquitina-Proteína Ligases / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina / Mutação Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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