Tim-3 and PD-1 regulate CD8+ T cell function to maintain early pregnancy in mice.
J Reprod Dev
; 63(3): 289-294, 2017 Jun 21.
Article
em En
| MEDLINE
| ID: mdl-28331165
ABSTRACT
During pregnancy, CD8+ T cells are important regulators in the balance of fetal tolerance and antiviral immunity. T-cell immunoglobulin mucin-3 (Tim-3) and programmed cell death-1 (PD-1) are well-recognized negative co-stimulatory molecules involved in viral persistence and tumor metastasis. Here, we demonstrate that CD8+ T cells co-expressing Tim-3 and PD-1 were down-regulated in the deciduae of female mice in abortion-prone matings compared with normal pregnant mice. In addition to their reduced numbers, the Tim-3+PD-1+CD8+ T cells produced lower levels of the anti-inflammatory cytokines interleukin (IL)-4 and IL-10, as well as a higher level of the pro-inflammatory cytokine interferon (IFN)-γ, relative to those from normal pregnancy. Furthermore, normal pregnant CBA/J females challenged with Tim-3- and/or PD-1-blocking antibodies were more susceptible to fetal resorption. These findings indicate that Tim-3 and PD-1 pathways play critical roles in regulating CD8+ T cell function and maintaining normal pregnancy.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prenhez
/
Linfócitos T CD8-Positivos
/
Perda do Embrião
/
Receptor de Morte Celular Programada 1
/
Receptor Celular 2 do Vírus da Hepatite A
Limite:
Animals
/
Pregnancy
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article