Cryptic exon incorporation occurs in Alzheimer's brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43.

Sun, Mingkuan; Bell, William; LaClair, Katherine D; Ling, Jonathan P; Han, Heather; Kageyama, Yusuke; Pletnikova, Olga; Troncoso, Juan C; Wong, Philip C; Chen, Liam L

Sun, Mingkuan; Bell, William; LaClair, Katherine D; Ling, Jonathan P; Han, Heather; Kageyama, Yusuke; Pletnikova, Olga; Troncoso, Juan C; Wong, Philip C; Chen, Liam L.

Afiliação

Sun M; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Bell W; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
LaClair KD; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Ling JP; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Han H; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Kageyama Y; Department of Biology, Johns Hopkins University, Baltimore, MD, 21218, USA.
Pletnikova O; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Troncoso JC; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Wong PC; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Chen LL; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Acta Neuropathol ; 133(6): 923-931, 2017 06.

Article em En | MEDLINE | ID: mdl-28332094

Assuntos

Doença de Alzheimer/metabolismo; Doença de Alzheimer/patologia; Encéfalo/metabolismo; Encéfalo/patologia; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Idoso; Idoso de 80 Anos ou mais; Doença de Alzheimer/genética; Núcleo Celular/metabolismo; Núcleo Celular/patologia; Estudos de Coortes; Éxons; Feminino; Humanos; Imuno-Histoquímica; Masculino; Neurônios/metabolismo; Neurônios/patologia; Proteinopatias TDP-43/metabolismo; Proteinopatias TDP-43/patologia

Palavras-chave

ALS/FTD; Alzheimer's disease; Cryptic exon; Hippocampal sclerosis; Neurodegeneration; TDP-43 proteinopathy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Proteínas de Ligação a DNA / Doença de Alzheimer Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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