A meta-analysis of the impact of human leukocyte antigen-G on the outcomes of IVF/ICSI.
Reprod Biomed Online
; 34(6): 611-618, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28336163
ABSTRACT
This analysis was performed to determine whether the presence of soluble human leukocyte antigen-G (sHLA-G) in embryo culture medium is predictive of clinical outcomes in IVF treatment. The outcomes of implantation, clinical pregnancy, multiple pregnancy and miscarriage, between groups with and without sHLA-G in embryo culture media, were analysed. Fifteen studies with a total of 6170 cases were included. Ten of them were prospective studies while five were retrospective studies. Embryo culture media with sHLA-G were associated with significantly higher implantation rate and clinical pregnancy rate when compared with those without; the odd ratios (ORs) were 2.66 [95% confidence interval (CI) 1.75-4.06, P < 0.00001], 3.79 (95% CI 2.69-5.33, P < 0.00001), respectively. There was no significant difference in the rate of multiple pregnancy (OR 1.87, 95% CI 0.55-6.31) and miscarriage (OR 0.77, 95% CI 0.52-1.16). The results suggested that the presence of sHLA-G in the embryo culture medium favoured higher implantation rate and pregnancy rate. However, the conclusion needs to be consolidated by further clinical studies using a more precise method of determination of sHLA-G and research on the physiological and molecular mechanisms of the beneficial effect of sHLA-G on early embryo development and implantation.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Taxa de Gravidez
/
Injeções de Esperma Intracitoplásmicas
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Antígenos HLA-G
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Female
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Humans
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Pregnancy
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article