Rational design, synthesis, and structure-activity relationships of 5-amino-1H-pyrazole-4-carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors.

Basu, Sujay; Prathipati, Philip; Thorat, Sachin; Ansari, Shariq; Patel, Meena; Jain, Vaibhav; Jinugu, Ramana R; Niranjan, Sanjay; De, Siddhartha; Reddy, Satyanarayana

Basu, Sujay; Prathipati, Philip; Thorat, Sachin; Ansari, Shariq; Patel, Meena; Jain, Vaibhav; Jinugu, Ramana R; Niranjan, Sanjay; De, Siddhartha; Reddy, Satyanarayana.

Afiliação

Basu S; Drug Discovery Facility, Advinus Therapeutics Ltd, Quantum Towers, Plot-9, Phase-I, MIDC, Hinjewadi, Pune 411 057, India. Electronic address: sujay.basu@advinus.com.
Prathipati P; Drug Discovery Facility, Advinus Therapeutics Ltd, Quantum Towers, Plot-9, Phase-I, MIDC, Hinjewadi, Pune 411 057, India.
Thorat S; Drug Discovery Facility, Advinus Therapeutics Ltd, Quantum Towers, Plot-9, Phase-I, MIDC, Hinjewadi, Pune 411 057, India.
Ansari S; Drug Discovery Facility, Advinus Therapeutics Ltd, Quantum Towers, Plot-9, Phase-I, MIDC, Hinjewadi, Pune 411 057, India.
Patel M; Drug Discovery Facility, Advinus Therapeutics Ltd, Quantum Towers, Plot-9, Phase-I, MIDC, Hinjewadi, Pune 411 057, India.
Jain V; Drug Discovery Facility, Advinus Therapeutics Ltd, Quantum Towers, Plot-9, Phase-I, MIDC, Hinjewadi, Pune 411 057, India.
Jinugu RR; Drug Discovery Facility, Advinus Therapeutics Ltd, Quantum Towers, Plot-9, Phase-I, MIDC, Hinjewadi, Pune 411 057, India.
Niranjan S; Drug Discovery Facility, Advinus Therapeutics Ltd, Quantum Towers, Plot-9, Phase-I, MIDC, Hinjewadi, Pune 411 057, India.
De S; Drug Discovery Facility, Advinus Therapeutics Ltd, Quantum Towers, Plot-9, Phase-I, MIDC, Hinjewadi, Pune 411 057, India.
Reddy S; Drug Discovery Facility, Advinus Therapeutics Ltd, Quantum Towers, Plot-9, Phase-I, MIDC, Hinjewadi, Pune 411 057, India.

Bioorg Med Chem ; 25(1): 67-74, 2017 01 01.

Article em En | MEDLINE | ID: mdl-28340988

Assuntos

Inibidores Enzimáticos/química; Inibidores Enzimáticos/farmacologia; Proteína Tirosina Fosfatase não Receptora Tipo 1/antagonistas & inibidores; Pirazóis/química; Pirazóis/farmacologia; Aminação; Ácidos Carboxílicos/química; Ácidos Carboxílicos/farmacologia; Desenho de Fármacos; Humanos; Simulação de Acoplamento Molecular; Proteína Tirosina Fosfatase não Receptora Tipo 1/metabolismo

Palavras-chave

Hydrophobic; Oxadiazole; Permeability; Pharmacophore; Protein tyrosine phosphatase 1B

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Inibidores Enzimáticos / Proteína Tirosina Fosfatase não Receptora Tipo 1 Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google