The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study.
J Am Acad Dermatol
; 77(1): 33-41.e1, 2017 Jul.
Article
em En
| MEDLINE
| ID: mdl-28341348
ABSTRACT
BACKGROUND:
There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen.OBJECTIVE:
This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE).METHODS:
In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation was done immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE.RESULTS:
Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22 subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects.LIMITATIONS:
Only 2 doses of PLE were given. Furthermore, subjects with skin phototypes I to III only were studied.CONCLUSION:
The results suggest that PLE can potentially be used as an adjunctive agent to lessen the negative photobiologic effects of UVB.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Raios Ultravioleta
/
Extratos Vegetais
/
Polypodium
Limite:
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article