Palladium-Catalyzed Formal (5 + 2) Annulation between ortho-Alkenylanilides and Allenes.
Org Lett
; 19(7): 1674-1677, 2017 04 07.
Article
em En
| MEDLINE
| ID: mdl-28345930
ABSTRACT
2-Alkenyltriflylanilides react with allenes upon treatment with catalytic amounts of Pd(OAc)2 and Cu(II) to give highly valuable 2,3-dihydro-1H-benzo[b]azepines, in good yields, and with very high regio- and diastereoselectivities. Density functional theory (DFT) calculations suggest that the C-H activation of the alkenylanilide involves a classical concerted metalation-deprotonation (CMD) mechanism.
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MEDLINE
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En
Ano de publicação:
2017
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Article