Novel tetrahydroacridine and cyclopentaquinoline derivatives with fluorobenzoic acid moiety induce cell cycle arrest and apoptosis in lung cancer cells by activation of DNA damage signaling.

Szymanski, Pawel; Olszewska, Paulina; Mikiciuk-Olasik, Elzbieta; Rózalski, Antoni; Maszewska, Agnieszka; Markiewicz, Lukasz; Cuchra, Magda; Majsterek, Ireneusz

Szymanski, Pawel; Olszewska, Paulina; Mikiciuk-Olasik, Elzbieta; Rózalski, Antoni; Maszewska, Agnieszka; Markiewicz, Lukasz; Cuchra, Magda; Majsterek, Ireneusz.

Afiliação

Szymanski P; 1 Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Medical University, Lódz, Poland.
Olszewska P; 1 Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Medical University, Lódz, Poland.
Mikiciuk-Olasik E; 1 Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Medical University, Lódz, Poland.
Rózalski A; 2 Department of Immunobiology of Bacteria, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Lódz, Poland.
Maszewska A; 2 Department of Immunobiology of Bacteria, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Lódz, Poland.
Markiewicz L; 3 Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, Lódz, Poland.
Cuchra M; 3 Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, Lódz, Poland.
Majsterek I; 3 Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, Lódz, Poland.

Tumour Biol ; 39(3): 1010428317695011, 2017 Mar.

Article em En | MEDLINE | ID: mdl-28351316

Assuntos

Acridinas/administração & dosagem; Neoplasias Pulmonares/tratamento farmacológico; Quinolinas/administração & dosagem; Proteína Supressora de Tumor p53/biossíntese; Acridinas/química; Apoptose/efeitos dos fármacos; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Dano ao DNA/efeitos dos fármacos; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/patologia; Proteínas de Neoplasias/biossíntese; Fosforilação; Quinolinas/química; Transdução de Sinais/efeitos dos fármacos; Proteína Supressora de Tumor p53/genética

Palavras-chave

Acridine derivatives; DNA damage signaling; lung cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Acridinas / Proteína Supressora de Tumor p53 / Neoplasias Pulmonares Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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