Efficient Binding of the NOS1AP C-Terminus to the nNOS PDZ Pocket Requires the Concerted Action of the PDZ Ligand Motif, the Internal ExF Site and Structural Integrity of an Independent Element.

Li, Li-Li; Cisek, Katryna; Courtney, Michael J

Li, Li-Li; Cisek, Katryna; Courtney, Michael J.

Afiliação

Li LL; Molecular Signalling Laboratory, Department of Neurobiology, A. I. Virtanen Institute, University of Eastern FinlandKuopio, Finland; Neuronal Signalling Laboratory, Turku Centre for Biotechnology, University of TurkuTurku, Finland.
Cisek K; Molecular Signalling Laboratory, Department of Neurobiology, A. I. Virtanen Institute, University of Eastern Finland Kuopio, Finland.
Courtney MJ; Molecular Signalling Laboratory, Department of Neurobiology, A. I. Virtanen Institute, University of Eastern FinlandKuopio, Finland; Neuronal Signalling Laboratory, Turku Centre for Biotechnology, University of TurkuTurku, Finland.

Front Mol Neurosci ; 10: 58, 2017.

Article em En | MEDLINE | ID: mdl-28360833

Palavras-chave

PDZ domain; ZLc-002-1; dissociation constant; fluorescence polarization; molecular dynamics simulation; multi-site binding; nNOS; nos1ap

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article