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Changing epidemiology of candidaemia in Australia.
Chapman, Belinda; Slavin, Monica; Marriott, Debbie; Halliday, Catriona; Kidd, Sarah; Arthur, Ian; Bak, Narin; Heath, Christopher H; Kennedy, Karina; Morrissey, C Orla; Sorrell, Tania C; van Hal, Sebastian; Keighley, Caitlin; Goeman, Emma; Underwood, Neil; Hajkowicz, Krispin; Hofmeyr, Ann; Leung, Michael; Macesic, Nenad; Botes, Jeannie; Blyth, Christopher; Cooley, Louise; George, C Robert; Kalukottege, Pankaja; Kesson, Alison; McMullan, Brendan; Baird, Robert; Robson, Jennifer; Korman, Tony M; Pendle, Stella; Weeks, Kerry; Liu, Eunice; Cheong, Elaine; Chen, Sharon.
Afiliação
  • Chapman B; Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia.
  • Slavin M; Department of Infectious Diseases, Peter MacCallum Cancer Centre, Victorian Infectious Diseases Service at the Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Marriott D; Department of Microbiology and Infectious Diseases, St Vincent's Hospital, Sydney, NSW, Australia.
  • Halliday C; Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, Westmead Hospital, Westmead, Sydney, NSW, Australia.
  • Kidd S; National Mycology Reference Centre, SA Pathology, Adelaide, SA, Australia.
  • Arthur I; Department of Microbiology, PathWest Laboratory Medicine, QEII Medical Centre, Nedlands, WA, Australia.
  • Bak N; Department of Infectious Diseases, Royal Adelaide Hospital, Adelaide, SA, Australia.
  • Heath CH; Department of Microbiology and Infectious Diseases, Royal Perth Hospital, Department of Microbiology, PathWest Laboratory Medicine Fiona Stanley Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia.
  • Kennedy K; Department of Infectious Diseases and Microbiology, Canberra Hospital, Australian National University Medical School, Canberra, ACT, Australia.
  • Morrissey CO; Department of Infectious Diseases, Alfred Health and Monash University, Melbourne, VIC, Australia.
  • Sorrell TC; Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia.
  • van Hal S; Centre for Infectious Diseases and Microbiology Westmead Institute for Medical Research, Westmead Hospital and the Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, NSW, Australia.
  • Keighley C; Department of Infectious Diseases and Microbiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
  • Goeman E; Centre for Infectious Diseases and Microbiology Westmead Institute for Medical Research, Westmead Hospital and the Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, NSW, Australia.
  • Underwood N; Department of Microbiology and Infectious Diseases, St Vincent's Hospital, Sydney, NSW, Australia.
  • Hajkowicz K; Infection Management Services, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
  • Hofmeyr A; Department of Infectious Diseases, Royal Brisbane and Women's Hospital, School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
  • Leung M; Department of Microbiology and Infectious Diseases, Liverpool Hospital, Sydney, NSW, Australia.
  • Macesic N; Department of Microbiology, PathWest Laboratory Medicine, QEII Medical Centre, Nedlands, WA, Australia.
  • Botes J; Department of Infectious Diseases, Austin Hospital, Heidelberg, VIC, Australia and Division of Infectious Diseases, Columbia University Medical Center, New York City, NY, USA.
  • Blyth C; Department of Microbiology, SEALS South Pathology, Wollongong Hospital, Wollongong, NSW, Australia.
  • Cooley L; School of Paediatrics and Child Health, University of Western Australia, Subiaco, WA, Australia and Department of Infectious Diseases, Princess Margaret Hospital, Subiaco, WA, Australia.
  • George CR; Department of Microbiology and Infectious Diseases, Royal Hobart Hospital, Hobart, Tasmania, Australia.
  • Kalukottege P; Department of Microbiology, South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney, NSW, Australia.
  • Kesson A; Department of Microbiology, Pathology -North, Hunter, Newcastle, NSW, Australia.
  • McMullan B; Department of Infectious Diseases and Microbiology, The Children's Hospital, Westmead and Discipline of Paediatrics and Child Health, University of Sydney, Sydney, NSW, Australia.
  • Baird R; Department of Immunology and Infectious Diseases, Sydney Children's Hospital, Randwick, NSW, Australia.
  • Robson J; Department of Microbiology, Royal Darwin Hospital, Darwin, NT, Australia.
  • Korman TM; Sullivan and Nicolaides Pathology, Brisbane, Queensland, Australia.
  • Pendle S; Monash Infectious Diseases, Monash University and Monash Health, Melbourne, VIC, Australia.
  • Weeks K; Department of Microbiology, Australian Clinical Laboratories, Sydney, NSW, Australia.
  • Liu E; Department of Microbiology, Pathology North, Royal North Shore Hospital, Sydney, NSW, Australia.
  • Cheong E; Department of Microbiology and Infectious Diseases, Concord Hospital, Sydney, NSW, Australia.
  • Chen S; Department of Microbiology and Infectious Diseases, Concord Hospital, Sydney, NSW, Australia.
J Antimicrob Chemother ; 72(4): 1103-1108, 2017 04 01.
Article em En | MEDLINE | ID: mdl-28364558
ABSTRACT

Objectives:

Knowledge of contemporary epidemiology of candidaemia is essential. We aimed to identify changes since 2004 in incidence, species epidemiology and antifungal susceptibilities of Candida spp. causing candidaemia in Australia.

Methods:

These data were collected from nationwide active laboratory-based surveillance for candidaemia over 1 year (within 2014-2015). Isolate identification was by MALDI-TOF MS supplemented by DNA sequencing. Antifungal susceptibility testing was performed using Sensititre YeastOne™.

Results:

A total of 527 candidaemia episodes (yielding 548 isolates) were evaluable. The mean annual incidence was 2.41/105 population. The median patient age was 63 years (56% of cases occurred in males). Of 498 isolates with confirmed species identity, Candida albicans was the most common (44.4%) followed by Candida glabrata complex (26.7%) and Candida parapsilosis complex (16.5%). Uncommon Candida species comprised 25 (5%) isolates. Overall, C. albicans (>99%) and C. parapsilosis (98.8%) were fluconazole susceptible. However, 16.7% (4 of 24) of Candida tropicalis were fluconazole- and voriconazole-resistant and were non-WT to posaconazole. Of C. glabrata isolates, 6.8% were resistant/non-WT to azoles; only one isolate was classed as resistant to caspofungin (MIC of 0.5 mg/L) by CLSI criteria, but was micafungin and anidulafungin susceptible. There was no azole/echinocandin co-resistance.

Conclusions:

We report an almost 1.7-fold proportional increase in C. glabrata candidaemia (26.7% versus 16% in 2004) in Australia. Antifungal resistance was generally uncommon, but azole resistance (16.7% of isolates) amongst C. tropicalis may be emerging.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Candida / Candidemia / Antifúngicos Tipo de estudo: Incidence_studies / Prognostic_studies / Screening_studies Limite: Female / Humans / Male País/Região como assunto: Oceania Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Candida / Candidemia / Antifúngicos Tipo de estudo: Incidence_studies / Prognostic_studies / Screening_studies Limite: Female / Humans / Male País/Região como assunto: Oceania Idioma: En Ano de publicação: 2017 Tipo de documento: Article