Dopamine dependent setting of a circadian oscillator underlying the memory for time of day.
Neurobiol Learn Mem
; 141: 78-83, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-28366864
ABSTRACT
Animals learn and remember the time of day that significant conditions occur, and anticipate recurrence at 24-h intervals, even after only one exposure to the condition. On several place-conditioning tasks, animals show context avoidance or preference only near the time of day of the experience. The memory for time of day is registered by a circadian oscillator that is set at the time of the training. We show that manipulations of dopamine (DA) neurotransmission can set a time memory in place preference and avoidance tasks, indicating that time of day is part of the context that is learned. Single injections of the DA agonist, d-amphetamine sulfate given without further exposure to the conditioning apparatus, can reset the timing of anticipatory behavior evoked by previously acquired place-event associations. The data support a model for time memory in which DA signaling sets the phase of a circadian oscillator, which returns to the same state at regular 24-h intervals. The data also raise the possibility that some apparent impairments of memory formation or retention could reflect post-experience resetting of the optimal retrieval time rather than impairment of memory or retrieval per se.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Relógios Biológicos
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Ritmo Circadiano
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Inibidores da Captação de Dopamina
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Antagonistas de Dopamina
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Dextroanfetamina
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Haloperidol
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Memória
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article