The lca as an onco-fetal gene: its expression in human fetal liver.
Oncogene
; 2(5): 523-6, 1988 May.
Article
em En
| MEDLINE
| ID: mdl-2836781
ABSTRACT
The lca-transforming DNA was isolated from human hepatocellular carcinomas. This gene has no homology with known transforming DNA from human sources, and its role in neoplastic tissue formation has been left unanswered. In this communication, we report that RNAs prepared from human fetal livers hybridize to the lca DNA probe. The RNA is 1.8 kilobase in size and appears in the fetal liver only for a limited period during its development, viz. 19 weeks through 24 weeks of gestation. No other tissues carry detectable levels of the lca messenger RNA. Fetal hepatocytes at 5 weeks of gestation showed no transcripts of lca, but upon culturing for 2 more weeks in vitro, the cells became producers of the lca messenger RNA. These results suggest that the lca plays some role in the proliferative stage of the liver.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proto-Oncogenes
/
DNA de Neoplasias
/
Carcinoma Hepatocelular
/
Fígado
/
Neoplasias Hepáticas
Limite:
Humans
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article