Sustainable Practices in Medicinal Chemistry Part 2: Green by Design.
J Med Chem
; 60(14): 5955-5968, 2017 07 27.
Article
em En
| MEDLINE
| ID: mdl-28375009
With the development of ever-expanding synthetic methodologies, a medicinal chemist's toolkit continues to swell. However, with finite time and resources as well as a growing understanding of our field's environment impact, it is critical to refine what can be made to what should be made. This review seeks to highlight multiple cheminformatic approaches in drug discovery that can influence and triage design and execution impacting the likelihood of rapidly generating high-value molecules in a more sustainable manner. This strategy gives chemists the tools to design and refine vast libraries, stress "druglikeness", and rapidly identify SAR trends. Project success, i.e., identification of a clinical candidate, is then reached faster with fewer molecules with the farther-reaching ramification of using fewer resources and generating less waste, thereby helping "green" our field.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Preparações Farmacêuticas
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Química Farmacêutica
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Descoberta de Drogas
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Química Verde
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article