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Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease.
Bouziat, Romain; Hinterleitner, Reinhard; Brown, Judy J; Stencel-Baerenwald, Jennifer E; Ikizler, Mine; Mayassi, Toufic; Meisel, Marlies; Kim, Sangman M; Discepolo, Valentina; Pruijssers, Andrea J; Ernest, Jordan D; Iskarpatyoti, Jason A; Costes, Léa M M; Lawrence, Ian; Palanski, Brad A; Varma, Mukund; Zurenski, Matthew A; Khomandiak, Solomiia; McAllister, Nicole; Aravamudhan, Pavithra; Boehme, Karl W; Hu, Fengling; Samsom, Janneke N; Reinecker, Hans-Christian; Kupfer, Sonia S; Guandalini, Stefano; Semrad, Carol E; Abadie, Valérie; Khosla, Chaitan; Barreiro, Luis B; Xavier, Ramnik J; Ng, Aylwin; Dermody, Terence S; Jabri, Bana.
Afiliação
  • Bouziat R; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Hinterleitner R; Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • Brown JJ; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Stencel-Baerenwald JE; Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • Ikizler M; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Mayassi T; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Meisel M; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Kim SM; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Discepolo V; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Pruijssers AJ; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Ernest JD; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Iskarpatyoti JA; Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • Costes LM; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Lawrence I; Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • Palanski BA; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Varma M; Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • Zurenski MA; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Khomandiak S; Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, and CeInGe-Biotecnologie Avanzate, Naples, Italy.
  • McAllister N; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Aravamudhan P; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Boehme KW; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Hu F; Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • Samsom JN; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Reinecker HC; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Kupfer SS; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Guandalini S; Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus University Medical Center Rotterdam-Sophia Children's Hospital, Rotterdam, Netherlands.
  • Semrad CE; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Abadie V; Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • Khosla C; Department of Chemistry, Stanford University, Stanford, CA, USA.
  • Barreiro LB; Division of Gastroenterology, Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Xavier RJ; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Ng A; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Dermody TS; Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • Jabri B; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Science ; 356(6333): 44-50, 2017 04 07.
Article em En | MEDLINE | ID: mdl-28386004
ABSTRACT
Viral infections have been proposed to elicit pathological processes leading to the initiation of T helper 1 (TH1) immunity against dietary gluten and celiac disease (CeD). To test this hypothesis and gain insights into mechanisms underlying virus-induced loss of tolerance to dietary antigens, we developed a viral infection model that makes use of two reovirus strains that infect the intestine but differ in their immunopathological outcomes. Reovirus is an avirulent pathogen that elicits protective immunity, but we discovered that it can nonetheless disrupt intestinal immune homeostasis at inductive and effector sites of oral tolerance by suppressing peripheral regulatory T cell (pTreg) conversion and promoting TH1 immunity to dietary antigen. Initiation of TH1 immunity to dietary antigen was dependent on interferon regulatory factor 1 and dissociated from suppression of pTreg conversion, which was mediated by type-1 interferon. Last, our study in humans supports a role for infection with reovirus, a seemingly innocuous virus, in triggering the development of CeD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença Celíaca / Infecções por Reoviridae / Células Th1 / Glutens / Inflamação / Antígenos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença Celíaca / Infecções por Reoviridae / Células Th1 / Glutens / Inflamação / Antígenos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article