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Ligand-Enabled Pd(II)-Catalyzed Bromination and Iodination of C(sp3)-H Bonds.
Zhu, Ru-Yi; Saint-Denis, Tyler G; Shao, Ying; He, Jian; Sieber, Joshua D; Senanayake, Chris H; Yu, Jin-Quan.
Afiliação
  • Zhu RY; Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Saint-Denis TG; Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Shao Y; Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • He J; Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Sieber JD; Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc. , 900 Ridgebury Road, Ridgefield, Connecticut 06877, United States.
  • Senanayake CH; Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc. , 900 Ridgebury Road, Ridgefield, Connecticut 06877, United States.
  • Yu JQ; Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
J Am Chem Soc ; 139(16): 5724-5727, 2017 04 26.
Article em En | MEDLINE | ID: mdl-28391681
ABSTRACT
We herein report the palladium(II)-catalyzed bromination and iodination of a variety of α-hydrogen-containing carboxylic acid and amino acid-derived amides. These reactions are exclusively enabled by quinoline-type ligands. The halogenated products obtained in this reaction are highly versatile and rapidly undergo further diversification. Further, we report the first example of a free carboxylic acid-directed Pd(II)-catalyzed C(sp3)-H bromination, enabled by quinoline ligands.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paládio / Quinolinas / Ácidos Carboxílicos / Amidas / Hidrocarbonetos Bromados / Hidrocarbonetos Iodados Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paládio / Quinolinas / Ácidos Carboxílicos / Amidas / Hidrocarbonetos Bromados / Hidrocarbonetos Iodados Idioma: En Ano de publicação: 2017 Tipo de documento: Article